Amprolium hydrochloride 20% W/S
For Veterinary Use Only
Each gram contains
Amprolium hydrochloride 200mg
It is used as a preventive or therapeutic agent against Eimeria infections in poultry, especially E. tenella, E. necatrix, E. acervulina and E. praecox.
It is effective against other protozoal infections like Histomoniasis (Blackhead) in turkeys and poultry; against coccidiosis in calves, sheep and goats;
against amaebiasis in various species.
DOSAGE AND ADMINISTRATION:
For oral administration:
Calves, sheep and goats:
Preventive: 1 g per 40 kg body weight through drinking water or milk for 21 days.
Curative: 1 g per 20 kg body weight through drinking water or milk for 5 days.
Preventive : 1 g per 3 litres of drinking water for 1-2 weeks.
Curative : 1 g per 1.5-2 litres of drinking water for 5-7 days.
Do not use in layers producing eggs for human consumption.
For meat: 3 days
Store in dry dark place between 5℃ and 25 ℃,
100g 500g 1kg sachet
VALIDITY: 2 years
How to use Amprolium Hydrochloride?
Background and overview
Coccidiosis is a parasitic disease that damages the intestines of poultry. It is a disease that many commercial poultry farmers are afraid of. It is a very common phenomenon that death loss is more than 20%, and it can cause poultry meat and egg production. Serious losses occurred. In the 1950s, the chemically synthesized anticoccidial drug Nicarbazine was used, and drug control has become the most effective, convenient and commonly used method for coccidiosis. The world’s annual consumption of coccidiosis drugs is about 320 million US dollars. With the development of the aquaculture industry and the impact of coccidiosis on the aquaculture industry, the demand for anticoccidiosis drugs will increase year by year.
Amprolium hydrochloride, the English name is Amprolium Hydrochloride, and the chemical name is 1-(4-amino-2-n-propylpyrimidine-5-methylene)-2-picoline hydrochloride. Amproline hydrochloride was first developed by Merck’s Rogers in the 1960s. It is easily soluble in water, stable in nature, unchanged for 5 years at room temperature and below 40°C, and has the advantages of low toxicity, large safety range, small residue and no withdrawal period.
The drug mainly acts on the first generation of schizonts (the peak of action is the third day of the coccidial cycle) and prevents the formation of merozoites. Data shows that amproline also has a certain effect on the sexual cycle (gametogenesis stage) and sporozoites. Inhibition. The chemical structure of the drug is similar to thiamine. It replaces thiamine during the metabolism of coccidia, causing thiamine deficiency in the worm body and interfering with its metabolism. It can inhibit the growth and development of coccidian schizonts, and it also has an inhibitory effect on gametophytes and sporophytes. .
In recent years, coccidiosis has developed serious resistance to many drugs, leading to many cases of failure in prevention and treatment. Because of the unique mechanism of action of amprofen hydrochloride, the uptake of thiamine by coccidia can be inhibited by competitively inhibiting coccidia. The development of coccidia is currently widely used in countries all over the world, and the global annual demand is more than 1,000 tons. The United States Phpro (Israel KOFFOLK Co., Ltd.) is the world’s main supplier of amprofen hydrochloride, and its production capacity and market share have reached the global level. 1/2.
At present, the drug is only produced in a small amount in China, and there are fewer reports on the related synthesis process. The impact of coccidiosis on the chicken industry is becoming more and more serious. At the same time, the research and development of new coccidiosis drugs requires a lot of manpower, material and financial resources, and there is a certain research cycle. Therefore, the development of domestic amproline and the realization of large-scale industrial production are of great significance for meeting domestic demand and foreign trade export, and the prospects are broad.
Usage and dosage
Mixed feeding: 125g poultry per ton of feed.
Amproline hydrochloride is used in chickens, rabbits, calves and lambs, and is effective against chicken tender and Eimeria acervulina, as well as lamb and calf coccidia. It is suitable for use with other drugs to make water-soluble powder or premix. It is the main anticoccidial drug for laying hens. The product has low toxicity, large safety range, few residues, and no withdrawal period. It is often combined with ethoxyamide benzyl and sulfaquinoxaline to expand the anti-coccidial spectrum and enhance the anti-coccidial effect. Combined use with sulfaquinoxaline also has a good inhibitory effect on concurrent bacterial infections, and is currently a widely used anticoccidial drug.
Although this product is stable in nature, it can be mixed with a variety of vitamins, minerals, and antibacterial drugs, but it is still slowly decomposed in chicken feed. Stored at room temperature for 60 days, the average failure is 8%. Therefore, this product should still be prepared for immediate use. It is often used in combination with ethoxyamide benzyl and sulfaquinoline to enhance the efficacy. Calves and lambs fed with large doses for more than 20 days can cause cerebral cortex necrosis caused by thiamine deficiency, and neurological symptoms can occur. Laying hens are forbidden. The drug withdrawal period is 7 days for broilers and 1 day for beef cattle.